"Genferon Light" (spray): instructions for use, reviews

Health

When there is any discomfort, I want toquickly get rid of it, so finding a drug that can help in the shortest time to help in this situation, holds an important place in the selection of treatment methods. One of the tools that begin to immediately act after the introduction of acute respiratory infections and flu is the drug "Genferon Light" (spray), effective for both treatment and prevention of viral colds. This is due to the correct choice of the method of administration, through which the drug is delivered directly to the site of the pathogen in the body (gateway infection), as well as the composition of the drug, which includes interferon and taurine.

Pharmacological group

This drug belongs to the groupimmunomodulators. It consists of recombinant human interferon alpha-2b, obtained with the strain of Escherichia coli bacteria, into which the gene of human interferon, possessing the property of increasing the protective forces of the organism, and the substance taurine, causing the antimicrobial effect, was built by genetic engineering.

The drug exhibits a complex action:

immunomodulating and stimulating, which consists in the harmonization and strengthening of the protective forces of the organism, manifested at the expense of alpha-2b-interferon;
antiviral, characterized by the suppression of the activity and the ability to propagate the causative agent of the disease at the site of its entry into the body;
antiproliferative, consisting in inhibition of reproduction of bacteria and cancer cells;
mediated antibacterial;
anti-inflammatory.

Having immunostimulating and antiviralactivity, the drug "Genferon Light" (spray), reviews of which indicate its high effectiveness in ARVI, after introduction into the nasal passages begins to act immediately, suppressing the development of infection at the earliest stages.

Mechanism of action

Getting on the mucosa of the nasal cavity, the drug substance has a pronounced local effect in the source of infection and the overall effect on the body as a whole.

The general mechanism is due to the properties of the active ingredients contained in the preparation "Genferon Light" (spray):

antiviral effect is associated with the activation of intracellular enzymes that suppress the multiplication of viruses;
immunomodulating activity is due toincreased reactivity of the body's immune forces, which is associated with the stimulation of CD8 + T-killers, NK cells, increased differentiation of B-lymphocytes and the production of antibodies and other cellular immunity factors;
there is an incentivemonocyte-macrophage systems and phagocytosis processes, as well as an increase in the expression of the molecules of the main complex responsible for the histocompatibility of the first type (which increases the probability of recognition of infected cells by agents of the immune system of the human body;
activation of white blood cells, occurringunder the action of interferon, which is part of the drug, allows you to stimulate protective bodies of all layers of the mucous membrane, ensuring their direct participation in suppression of pathological foci;
In addition, under the stimulating effect of human interferon, the production of a protective factor such as secretory immunoglobulin A is restored;
the antibacterial effect is indirectly dependent on the enhancement of the immune response resulting from the administration of interferon;
normalization of metabolic processes and increase in the regenerative capacity of tissues occurs under the action of taurine, which has membrane-stabilizing and immunomodulating activity;
taurine, being an antioxidant, prevents the accumulation of free oxygen in tissues, which prevents the spread of pathological processes in them;
interferon, changing metabolic processes in the cells of the smallest pathogens of infections, such as viruses or chlamydia, can stop the process of their reproduction and further spread.

Form of issue

The drug "Genferon" is produced in the form of candles andspray. The latter is a light transparent liquid, enclosed under pressure in a bottle of dark glass, ending with a dispenser equipped with a safety cap. The packaging is designed for 100 doses containing 50 000 IU of interferon alpha-2b human recombinant and 0.001 grams of taurine in each. Of the additional components can be identified disodium edetate dihydrate, glycerol, dextran, polysorbate, sodium and potassium chloride, peppermint oil, which must be taken into account if there is an individual intolerance to any of these substances. Suppositories intended for both rectal and vaginal administration are dispensed in two dosages (120,000 and 250,000 IU), which allows them to be administered to both adults and children in accordance with the need.

Indications for use

The drug "Genferon Light" (spray) showed a higheffectiveness in clinical studies on the treatment and prevention of influenza and other acute respiratory infections in adults and children older than 14 years, which allows them to recommend it for this purpose.

This spray can not be regarded only as a means offrom the common cold, because it acts in a complex manner on the state of the whole organism as a whole, suppressing the multiplication of viruses at the site of introduction (actually the mucous membrane of the respiratory system), excluding the development of the concomitant bacterial microflora and stimulating the human defenses.

Such a complex action allows for many diseases to recommend the drug "Genferon Light" (spray). The instruction speaks about its high efficiency:

as a means of treating various viral diseases, mainly the airways, and preventing their occurrence, especially during epidemics;
as an auxiliary medicine for acute and chronic sinusitis, bronchitis, pharyngitis, laryngitis, tracheitis, tonsillitis and other diseases;
to restore local immunity in the period after the cure for influenza and other ARVI;
in preparation for routine surgical interventions on the ENT organs and after them.

Contraindications

The drug "Genferon Light" (spray), reviews about the treatment of which indicate effective suppression of the common cold at the initial stages, can not be used by everyone. Do not assign it:

people who are hypersensitive to interferon alpha-2b, taurine, or other components that make up the drug;
children up to the age of 14, since the spray is only released with a dosage for adults;
patients with epilepsy or severe heart diseases.

Patients with a tendency to develop nasal bleeding should use the remedy with caution.

The drug "Genferon Light" (spray): instructions for use, dosage

When the very first signs of the disease appear, it is necessary to begin treatment with this medication. For correct use it is necessary to observe several rules:

After removing the protective cap, press the dispenser several times until a trickle of medicine appears (when taking the unused bottle);
holding the spray strictly vertically with a short push (1 dose of active ingredient) inject the medicine into each nostril in turn;
To avoid the spread of infection, each bottle must be used individually.

Recommend two schemes of application:

according to the first, one dose of medicine is injected into each nostril three times a day for five days;
the second option is to prescribe a spray dose in each nostril for the first 3-4 hours, injecting the medicine every 20 minutes, followed by the introduction of the drug 3-4 days to 5 times a day.

The maximum allowable daily amount of the drug substance is 10 doses.

The drug "Genferon Light" (spray): instructions for use for children

This immunomodulator is produced in twodosage forms - like rectal suppositories, with different content of the active substance, and in the form of a spray. It is the content of the drug base that determines the possibility of prescribing this drug to children. Candles are produced in two dosages: with a content of 250,000 IU of interferon alfa-2b, which is prescribed to adults and children over 7 years old, and with a dose of 125,000 IU, which can be used even in the treatment of newborns. The instruction prohibits the use of the drug "Genferon Light" (spray) for children. Reviews note the good efficacy of suppositories for the complex treatment of acute respiratory viral infections, therefore, many express their wishes for the appearance of a spray for children as more convenient to use. At the moment, it is allowed to appoint him only when the child reaches 14 years of age.

Use during pregnancy

A special condition of the female body associated withcarrying a baby requires a careful approach to the choice of drugs, as many of them are completely contraindicated to the expectant mother or are prescribed with caution if the intended benefits outweigh the potential risk to the fetus. The use of the drug "Genferon Light" (spray) during pregnancy is allowed at any time, as studies have not revealed the negative impact of this drug on the body of the fetus. On the contrary, if there is a high risk of infection (for example, in the season of increased morbidity or in contact with already ill), the future mother is recommended to use this spray for preventive purposes. This is due to the fact that the organism of a pregnant woman is more susceptible to colds of any etiology due to a decrease in its resistance to the action of harmful factors.

Breastfeeding Spray Use

The ban on the use of various kinds of drugsbreastfeeding time is due to the fact that the active ingredient, penetrating into breast milk, can also get into the baby’s body, which is especially dangerous in the case of taking drugs not prescribed to infants. The drug "Genferon Light" (spray) during lactation can be used because it does not penetrate the cellular barrier of the mammary glands. On the contrary, the stimulation of the body's defenses by the mother indirectly enhances the immunity of the child. In addition, although the drug “Genferon” in the form of a spray is not indicated for children under 14 years old (solely because of the “adult” dosage), candles containing this substance are allowed to be used from the neonatal period for various viral infections.

Side effect

Many doctors recommend aspreventive measures "Genferon Light" (spray). Instructions for use do not note the specific side effects of its use. Occasionally, phenomena characteristic of any type of interferon alfa-2b may occur, manifested by chills, fever, fatigue, loss of appetite, muscle and headache, and sweating. Such effects occur mainly with the introduction of the drug in excess of 10,000,000 IU per day. The occurrence of such a reaction requires consultation with a doctor about the selection of a different dose or other medication.

Compatibility with other drugs

In relation to interaction with other substancesdrug "Genferon Light" (nasal spray) instructions for use does not give specific instructions. Almost all medicaments are compatible with this dosage form. The only condition is the inadmissibility of the simultaneous appointment of nasal drops intended to combat catarrhal processes in the nasal cavity and this drug, which can reduce their effectiveness. Therefore, these medicinal groups should be used, observing the principle of separate administration.

Reviews

Most patients who used the drug“Genferon Light” (spray), speak of its high effectiveness in suppressing viral infections and the absence of side effects and discomfort from its use. Early use of the disease (at the very first signs of the disease) prevents the development of infection and suppresses it as soon as possible. As the only drawback, they indicate the absence of a nasal remedy for children under 14 years old, since the preparation Genferon Light for this age category, as already mentioned, exists only in the form of suppositories. This may cause rejection of this kind of therapy in young patients.

Thus, at the appearance of the slightest signsDevelopment of influenza or other acute respiratory diseases can be recommended to immediately use the drug "Genferon Light" (nasal spray), which has antiviral, immunostimulating and modulating effects, as well as anti-inflammatory effect, which will suppress the emerging disease at the very beginning and remove all the symptoms in a short time . The introduction of the drug in bypassing the digestive tract allows you to apply it, regardless of the meal at any convenient time, while the active substance is fully and quickly absorbed at the injection site. Intranasal use promotes the ingestion of the drug directly into the center of infection (since viral infections are transmitted mainly by airborne droplets), which manifests its effect both locally and in general on the entire body, which is due to partial absorption of the drug into the blood through the nasal mucosa moves.