Metoprolol-ratopharm

Metoprolol-ratopharm belongs to the group of drugs used in the treatment of cardiovascular diseases. Medication belongs to the pharmacological group of beta-blockers.

Tablets Metoprolol have antihypertensive, anti-angiogenic and antiarrhythmic effect. The drug interferes with the development of migraine.

Being a selective beta-blocker,Metoprolol-ratiopharm, with the use of average therapeutic doses, has less effect on organs that contain beta-2-adrenergic receptors (muscles of the skeleton, pancreas, smooth musculature of the peripheral arteries of the uterus and bronchi), as well as the metabolism of carbohydrates. Atherogenic action is expressed to the same extent as when using Propranolol. When taken in large doses of metoprolol-ratopharm has a blocking effect on beta-1 and beta-2-andrenoretseptory.

When applied inside, complete absorption is noted (95%). Metoprolol-ratopharm is distributed in tissues rapidly, penetrating the placental barrier, GEB.

The drug is metabolized in the liver, while the metabolites do not make a special contribution to the activity of beta-adrenergic blocking.

The drug is indicated for arterial hypertension(both independently and as part of combination therapy with other antihypertensive medications), with cardiac disorders of a functional nature accompanied by tachycardia. Assign Metoprolol in IHD: with myocardial infarction (as a secondary prophylaxis), angina (as a prophylaxis of attacks). The medication is indicated for the prevention of ventricular extrasystole and supraventricular tachycardia, as well as migraine attacks.

The drug is used with cautionwith diabetes mellitus, bronchial asthma, metabolic acidosis, renal failure, thyrotoxicosis, myasthenia gravis, psoriasis, obliterating peripheral vascular diseases, during pregnancy, and also in old age.

Metoprolol-ratopharm. Instructions

Initial dosage for arterial hypertensionis 50 mg. In the case of insufficient therapeutic effect, it is possible to increase it to 100-200 mg or prescribe additional other antihypertensive drugs. The daily dosage (maximum) is 200 mg.

The drug is taken orally, with water, once a day right after eating. The tablet should not be chewed.

As preventive measures for preventionthe initial daily dosage of the drug is 50 mg. If the effectiveness of therapy is insufficient, it is possible to increase it to 100-200 mg or additional prescription of other antianginal medicines. The maximum dosage per day is 200 mg.

In order to prevent migraine attacks, the drug is taken per day for 100-200 mg.

From 50 to 200 mg of the drug is prescribed for functional cardiac disorders, accompanied by tachycardia.

In the prevention of (secondary) myocardial infarction medication is prescribed in a dosage per day 200 mg.

With renal failure, the dosage does not require correction. Depending on the clinical state of liver failure, this may be necessary.

The medication has frequent side effectsmanifestations in the form of a bradycardia, cold in the lower extremities, orthostatic hypotension (including with a syncope), increased fatigue, dizziness, anxiety, increased nervous excitability, sexual dysfunction, nausea, abdominal pain, diarrhea or constipation, dyspnoea with physical exertion.

Cancellation of the drug is gradual withreduction in dosage for two weeks. It should be noted that a sharp rejection of the drug may trigger an increase in blood pressure, an increased risk of angina attacks.